Bioavailable SnF2 has a well-established history for a wide spectrum of therapeutic oral indications based on a myriad of published research establishing clinical effectiveness, including anti-plaque and anti-gingivitis efficacy. In addition to its known bactericidal/bacteriostatic and acid suppression effects, recent research has discovered a new plaque virulence modulation mechanism in which bioavailable SnF2 binds with gingival sulcus pathogenic endotoxins to reduce the inflammatory cascade at its inception stage, and thus prevent or reduce the clinical manifestations of gingivitis irrespective of plaque quantity. Regular toothbrushing with properly formulated bioavailable chemotherapeutic antimicrobial SnF2 dentifrice provides an easy to implement strategy not only for patients with existing gingivitis (treatment) but also for those with increased susceptibility or not yet manifesting symptoms (prevention).