As clinicians, we are responsible for implementing current evidence-based treatments. Therefore, it becomes critical that we understand what evidence-based practice really means. Not all evidence is created equal and not every conclusion of an article should be implemented. Critically interpreting evidence becomes a valuable part of the clinician’s responsibilities. This lecture will introduce the principles of evidence-based dentistry, how to develop, critically evaluate and implement scientific evidence into day-to-day practice and apply these principles to making the right decisions when advising patients on effective self-care in caries and periodontal disease prevention.